Cell Biology

Faculty and Research Interests

Kingsley Yin, PhD

Assistant Professor
Science Center 206a
856-566-6978
yinki@umdnj.edu

Education

University of Western Australia, 1991

Research Interests

Interferon-gamma in bacterial containment and wound healing during sepsis.Regulation of the activity of mononuclear cells in the lung during sepsis.

Recent Publications

1. Yin, K., Halushka, P.V., Yan, Y-T. & Wong, P. Y-K. (1994) Antiaggregatory activity of 8-epi-prostaglandin F2a and other F-series prostanoids and their binding to thromboxane  A2/prostaglandin H2 receptors in human platelets. J. Pharmacol. Exp. Ther., 270:1192-1196.

   Wong, P. Y-K., Yue, G., Yin, K., Miyasaka, M., Lane, C.L., Manning, A.M., Anderson, D.C. & Sun, F.F. (1995) Antibodies to ICAM-1 ameliorate the inflammatory response in acetic acid induced inflammatory bowel disease. J. Pharmacol. Exp. Ther., 274(1):475-480.

   Yin, K., McGiff, J.C. & Bell-Quilley, C.P. (1995) Role of chloride in the variable response of the kidney to cyclooxygenase inhibition. Am. J. Physiol., 268:F561-F568.

   Yin, K., Lai, P.S., Rodriguez, A., Spur, B.W. & Wong, P.Y-K. (1995). Antithrombotic effects of peroxynitrite: inhibition and reversal of aggregation in human platelets. Prostaglandins, 50:169-178.

   Yue, G., Sun, F.F., Dunn, C.L., Yin, K. & Wong, P.Y-K. (1996) The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease (IBD) in rats. J. Pharmacol. Exp. Ther., 276:265-270.

   Liu, P., Yin, K., Yue, G. & Wong, P.Y-K. (1996) Role of nitric oxide in hepatic ischemia-reperfusion with endotoxemia. J. Inflammation, 46:144-154.

   Hock, C.E., Yin, K., Yue, G. & Wong, P.Y-K. (1997) Effects of inhibition of nitric oxide synthase (NOS) by aminoguanidine in acute endotoxemia. Am. J. Physiol., 41:H843-H850.

   Forman, L.J., Liu, P., Nagele, R.G., Yin, K. & Wong, P.Y-K (1997) Augmentation of nitric oxide, superoxide, peroxynitrite production during cerebral ischemia and reperfusion in the rat. Neurochemical Research, 23(2):141-149.

   Liu, P., Yin, K., Nagele, R. And Wong, P.Y-K (1998) Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accumulation in hepatic ischemia-reperfusion in rats. J. Pharmacol. Exp. Ther., 284(3): 1139-1146.

   Yin, K., Hock, C.E., Tahamont, M. & Wong, P.Y-K. (1998) Time-dependent cardiovascular and inflammatory changes in acute endotoxemia. Shock, 9(6):434-442.

   Yin, K., Hock, C.E., Lai, P-S., Ross, J. & Yue, G. (1999) Role of interferon-g on lung inflammation following cecal ligation and puncture in rats. Shock, 12(3):215-221.

   Yin, K., Wilmanski, J., Wang, C., Qiu, G. & Tahamont, M. (2000) Lung compartmentalization of inflammatory cells in sepsis. Inflammation, 24(6):547-557.

   Sun, F.F., Lai, P-S., Yue, G., Yin, K., Nagele, R., Krzesicki, R.F., Chin, J.E. & Wong, P.Y-K. (2001) Pattern of cytokine and adhesion molecule mRNA expression in hapten-induced relapsing colon inflammation in the rat. Inflammation, 25(1):33-45.

   Qiu, G., Wang, C., Smith, R. Harrison, K. & Yin, K. (2001) Role of IFN-g in bacterial containment in a model of intra-abdominal sepsis. Shock, 16(6):425-429.

   Yue, G. Lai, P-S., Yin, K., Sun, F.F., Nagele, R.G., Liu, X., Linask, K.K., Wang, C., Lin, K-T. & Wong, P. Y-K. (2001) Colon epithelial cell death in TNBS-induced colitis is associated with increased iNOS expression and peroxynitrite production. J. Pharmacol. Exp. Ther., 297(3):915-925.

   Wang, C., Kuzma, M., Qiu, G. & Yin, K. (2003) Heterogenous and compartment specific activation of non-lymphocytic mononuclear cells in intra-abdominal sepsis. Experimental Lung Research, 29(7): 503-521.

   Qiu, G., Gribbin, E., Harrison, K., Sinha, N. & Yin, K. (2003) Inhibition of Gamma Interferon decreases bacterial load in peritonitis by accelerating peritoneal fibrin deposition and tissue repair. Infection and Immunity, 71(5): 2766-2774.

   Yin, K., Gribbin, E. & Wang, H. (2005) Interferon-g attenuates lethality after cecal ligation and puncture in rats: Implications of High Mobility Group Box-1. Shock, 24(4): 396-401.

   Yin, K., Gribbin, E., Emanuel, S., Orndorff, R., Walker, J., Weese, J. & Fallahnejad, M. Histochemical alterations in one lung ventilation. Journal of Surgical Research, 137: 16-20.

   Pahuja, M., Tran, C., Wang, H. & Yin, K.  (2008) Alveolar macrophage suppression in sepsis is associated with HMGB1 migration. Shock, 29(6):754-760.

   Yue, G., Shi, G., Azaro, M.A., Yang, Q., Hu, G., Luo, M., Yin, K., Nagele, R.G., Fine, D.H., Yang, J-M., &   Li, H. (2008) Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression. BMC Genomics, 9:608.