Cell Biology

Faculty and Research Interests

Bernd W. Spur, PhD

Continued Bibliography

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  1. Falsone G., Spur B. Simple synthesis of substituted 5,6-dihydro-2H-pyran-2-ones under mild conditions. Liebigs Ann. Chem. 1979, 751-756.
  2. Falsone G., Spur B. Synthesis of calcium-5, 5-dimethyl-2-oxo-5, 6-dihydro-2H-pyran-3, 4-dicarboxylic acid. Liebigs Ann. Chem. 1979, 923-926.
  3. Falsone G., Spur B. Simple synthesis of substituted 5,6-dihydro-2H-pyran-2-ones under mild conditions. Liebigs Ann. Chem. 1981, 565-568.
  4. Falsone G., Spur B. Synthesis of 3-methylendisubstituted 2-oxo-tetrahydro-furanes and their rearrangements to 5,6-dihydro-2H-pyran-2-ones. Arch. Pharm. (Weinheim Ger.) 1982, 315, 491-498.
  5. Falsone G., Spur B. Synthesis of substituted 5,6-dihydro-2H-pyran-2-ones and their reaction with bromine. Liebigs Ann. Chem. 1982, 191-195.
  6. Spur B., Falsone G., Crea A., Peters W., Koenig W. Synthesis of leukotriene E3. Arch. Pharm. (Weinheim Ger.) 1983, 316, 789-791.
  7. Spur B., Crea A., Peters W., Koenig W. Formation and structure determination of 5,6-epoxy-8, 11,14Z-eicosatrienoic acid and 5-oxo-8, 11,14Z-eicosatrienoic acid. Tetrahedron Lett. 1983, 24, 1755-1758.
  8. Bremm K. D., Brom J., Koenig W., Spur B., Crea A., Bhadki S., Lutz F., Fehrenbach F. J. Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins. Zentralbl. Bakteriol. Mikrobiol. Hyg. [A] 1983, 254, 500-514.
  9. Koenig W., Bremm K. D., Brom J., Spur B., Falsone G. Synthetic leukotrienes - their effects in biological models. Zentralbl. Bakteriol. Mikrobiol. Hyg. [A] 1983, 446-448.
  10. Koenig W., Bremm K. D., Muller P., Kunau W. H., Borgeat P., Spur B., Crea A., Falsone G. On the biological role of lipid chemotactic factors. Agents Actions Suppl. 1983, 12,167-185.
  11. Koenig W. Bremm K. D., Brom J., Pison U., Theobald K., Bohn A., Borgeat P., Spur B., Crea A., Falsone G. Interdependence of inflammatory signals in various immunological systems. Monogr. Allergy 1983, 18, 201-205.
  12. Falsone G., Spur B., Peters W. Synthesis of 3-methylenmonosubstituted-2-oxo-furanes from 3-phosphonolactones. Z. Naturforsch. B Anorg. Chem. Org. Chem. 1983, 493-496.
  13. Falsone G., Spur B., Hundt B. Synthesis of substituted 3-adamantyloxocumarins under piperidine acetate b-alanine catalysis. Arch. Pharm. (Weinheim Ger.) 1983, 316, 960-964.
  14. Falsone G., Spur B., Wingen H. P. Simple synthesis of 3-methyl-5, 6-dihydro-2H-pyran-2-ones and 3-methylcumarins under mild conditions. Arch. Pharm. (Weinheim Ger.) 1983, 316, 763-766.
  15. Falsone G., Spur B., Erdmann M., Peters W. Synthesis of 3-methylenmonosubstituted-2-oxo-tetrahydrofuranes by reaction of 2-ketolactones with wittig-compounds. Arch. Pharm. (Weinheim Ger.) 1983, 316, 530-536.
  16. Falsone G., Spur B. Reaction of 3-substituted 5,5-dialkyl-2-oxo-5, 6-dihydro-2H-pyrans with diazoalkanes. Arch. Pharm. (Weinheim Ger.) 1983, 315, 597-602.
  17. Spur B., Crea A., Peters W., Koenig W. Synthesis of 11,12,14,15-tetrahydroleukotriene C, D, E via A. Tetrahedron Lett. 1983, 24, 2135-2136.
  18. Spur B., Crea A., Peters W., Koenig W. Synthesis of 9,10,11,12,14,15-hexahydro-leukotriene E. Arch. Pharm. (Weinheim Ger.) 1983, 316, 372-374.
  19. Spur B., Crea A., Peters W., Koenig W. Synthesis and biological activities of 14,15-didehydro-leukotrienes and their methyl esters. Arch. Pharm. (Weinheim Ger.) 1983, 316, 968-970.
  20. Koenig W., Bohn A., Bremm K. D., Brom J., Theobald K., Spur B., Crea A. Die Rolle der Mastzelle bei allergischen und entzundlichen Erkrankungen. (Review). Prax. Klin. Pheumol. 1983, 37, 127-138.
  21. Bremm K. D., Brom J., Alouf J. E., Koenig W., Spur B., Crea A., Peters W. Generation of leukotrienes from human granulocytes by alveolysin from bacillus alvei. Infect. Immun. 1984, 44, 188-193.
  22. Spur B., Crea A., Peters W. Novel synthesis of methyl-6-formyl-trans-5,6-methano hexanoate. Z. Naturforsch. B Anorg. Chem. Org. Chem. 1984, 125-126.
  23. Spur B., Crea A., Peters W., Koenig W. Synthesis of leukotriene C5, D5 and E5. Arch. Pharm. (Weinheim Ger.) 1984, 317, 280-281.
  24. Jendralla H., Spur B. Cycloaddition reaction of silver ion stabilized 6-methoxy-cyclohepta-1-cis-4-trans diene. J. Chem. Soc. Chem. Commun. 1984, 887-888.
  25. Brom J., Bremm K. D., Spur B., Crea A., Theobald K., Koenig W. Subcellular localization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes. Immunology 1984, 51(3), 571-583.
  26. Spur B., Crea A., Peters W., Koenig W. Synthesis of 5,6-thialeukotrienes, inhibitors of the leukotriene biosynthesis. Arch. Pharm. (Weinheim Ger.) 1984, 317, 84-86.
  27. Spur B., Crea A., Peters W., Koenig W. Synthesis of leukotriene analogs. Arch. Pharm. (Weinheim Ger.) 1984, 317, 647-649.
  28. Spur B., Jendralla H., Crea A., Peters W., Koenig W. Synthesis of 7Z, 9E, 11E, 14Z-leukotrienes. Arch. Pharm. (Weinheim Ger.) 1984, 317, 651-653.
  29. Bremm K. D., Koenig W., Spur B., Crea A., Galanos C. Generation of slow reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes. Immunology 1984, 53(2),299-305.
  30. Spur B., Crea A., Peters W., Koenig W. Synthesis of leukotriene B3. Arch. Pharm. (Weinheim Ger.) 1985, 318, 225-228.
  31. Spur B., Jendralla H., Crea A., Peters W., Koenig W. Synthesis of 7Z, 9E, 11Z, 14E-leukotrienes, biological highly active SRS compounds. Arch. Pharm. (Weinheim Ger.) 1985, 318,567-569.
  32. Lee T. H., Hoover R. L., Williams J. D., Sperling R. L., Ravalese J., Spur B., Robinson D. R., Corey E. J., Lewis R. A., Austen K. F. Dietary enrichment with eicosapentaenoic and docosahexaenoic acids in human subjects impairs in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New Engl. J. Med. 1985, 312, 1217-1224.
  33. Koller M., Schonfeld W., Knoller J., Bremm K. D., Koenig W., Spur B., Crea A., Peters W. The metabolism of leukotrienes in blood plasma studied by high-performance liquid chromatography. Biochim. Biophys. Acta 1985, 833, 128-134.
  34. Sun F. F., Chau L. Y., Spur B., Corey E. J., Lewis R. A., Austen K. F. Identification of a high affinity specific leukotriene C4 binding protein in rat liver cytosol as glutathione S-transferase. J. Biol. Chem. 1986, 261(18), 8540-8546.
  35. Spur B., Jendralla H., Crea A., Peters W., Koenig W. Synthesis of leukotriene analogs. Arch. Pharm. (Weinheim Ger.) 1986, 319, 140-143.
  36. Sperling R. I., Weinblatt M., Robin J. L., Ravalese J., Hoover R. L., Coblyn J. S., Fraser P. A., Spur B. W., Robinson D. R., Lewis R. A., Austen K. F. Effects of dietary supplementation with marine fish oil on in vitro leukocyte leukotriene generation, leukocyte function and activity of disease in rheumatoid arthritis. Arthritis Rheum. 1987, 30(9), 988-997.
  37. Soberman R. J., Okita R. T., Fitzsimmons B., Rokach J., Spur B. W., Austen K. F. Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase. J. Biol. Chem. 1987, 262, 12421-12427.
  38. Heavy D. J., Soberman R. J., Lewis R. A., Spur B. W., Austen K. F. Critical considerations in the development of an assay for sulfidopeptide leukotrienes in plasma. Prostaglandins 1987, 33(5), 693-708.
  39. Topley N., Steadman R., Petersen M. M., Spur B. W., Williams J. D. Phagocytosis, the respiratory burst and the 5-lipoxygenase pathway are independently regulated in human polymorphonuclear leukocytes. Adv. Bioscience 1987, 66, 123-129.
  40. Lee T. H., Sethi T., Crea A. E. G., Peters W., Arm J. P., Horton C. E., Walport M. J., Spur B. W. Characterization of leukotriene B3. Comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Clin. Sci. 1988, 74, 467-475.
  41. Mahauthaman R., Howell C. J., Spur B. W., Youlten L. J. F., Clark T. J. H., Lessof M. H., Lee T. H. The generation and cellular distribution of leukotriene C4 in human eosinophils stimulated by unopsonized zymosa and glycan particles. J. Allergy Clin. Immunol. 1988, 81, 696-705.
  42. Arm J. P., Horton C. E., House F., Clark T. J. H., Spur B. W., Lee T. H. Enhanced generation of leukotriene B4 by neutrophils stimulated by unopsonized zymosan and by calcium ionophore following exercise-induced asthma. Am. Rev. Respir. Dis. 1988, 138, 47-53.
  43. Arm J. P., Spur B. W., Lee T. H. The effects of inhaled leukotriene E4 on the airways responsiveness to histamine in subjects with asthma and normal subjects. J. Allergy Clin. Immunol. 1988, 82, 654-660.
  44. Jacques C. A. J., Spur B. W., Crea A. E. G., Lee T. H. The contractile activities of lipoxin A4 and lipoxin B4 for guinea pig airways tissues. Br. J. Pharmacol. 1988, 95, 562-568.
  45. O'Hickey S. P., Arm J. P., Rees P. J., Spur B. W., Lee T. H. The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects. Eur. Resp. J. 1988, 1,913-917.
  46. Spur B. W., Jacques C., Crea A. E. G., Lee T. H. Lipoxins of the 5-series derived from eicosapentaenoic acid. Adv. Exp. Med. Biol. 1988, 229, 147-154.
  47. Yoshimoto T., Soberman R. J., Spur B. W., Austen K. F. Properties of highly purified leukotriene C4 synthese of guinea pig lung. J. Clin. Invest. 1988, 81, 866-871.
  48. Arm J. P., Horton C. E., Mencia-Huerta J.-M., House F., Eiser N. M., Clark T. J. H., Spur B. W., Lee T. H. The effects of dietary supplementation with fish oil lipids on mild bronchial asthma. Thorax 1988, 43, 84-92.
  49. Arm J. P., Horton C. E., Spur B. W., Mencia-Huerta J.-M., Lee T. H. The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma. Am. Rev. Resp. Dis. 1989, 139, 1395-1400.
  50. Arm J. P., O'Hickey S. P., Spur B. W., Lee T. H. Airways responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am. Rev. Resp. Dis. 1989, 140, 148-153.
  51. MacPherson T. L., Kemp A., Rogers M., Mallet A. I., Toia R. F., Spur B. W., Earl J. W., Chesterman C. N., Krilis S. A. Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis. Clin. Exp. Immunol. 1989, 77(3), 391-396.
  52. Lee T. H., Horton C. E., Kyan-Aung U., Haskard D., Crea A. E. G., Spur B. W. Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-phenylalanine. Clin. Sci. 1989, 77, 195-203.
  53. Steadman R., Petersen, M. M., Topley N., Williams D., Matthews N., Spur B. W., Williams J. D. Differential augmentation by recombinant human tumor necrosis factor of neutrophil responses to particulate zymosan and glycan. J. Immunol. 1990, 144, 2712-2718.
  54. Sala A., Civelli M., Oliva D., Spur B., Crea A., Folco G. C., Nicosia S. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea pig ileum. Eicosanoids 1990, 3(2),105-110.
  55. Grandordy B. M., Lacroix H., Mavoungou E., Krilis S., Crea A. E. G., Spur B. W., Lee T. H. Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils. Biochem. Biophys. Res. Commun. 1990, 167, 1022-1029.
  56. Arm J. P., O'Hickey S. P., Hawksworth R. J., Fong C. Y., Crea A. E. G., Spur B. W., Lee T. H. Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared to normal airways, but not to LTC4, LTD4, methacholine and histamine. Am. Rev. Respir. Dis. 1990, 142, 1112-1118.
  57. Maxwell D. L., Atkinson B. A., Spur B. W., Lessof M. H., Lee T. H. Skin responses to intradermal histamine and leukotrienes C4, D4 and E4 in patients with idiopathic urticaria and in normal subjects. J. Allergy Clin. Immunol. 1990, 86, 759-765.
  58. Steadman R., Topley N., Knowlden J., Spur B.W., Williams J. Leukotriene B4 generation by human monocytes and neutrophils stimulated by uropathogenic strains of Echerichia coli. Biochim. Biophys. Acta 1990, 1052, 264-272.
  59. Burke L. A., Crea A. E. G., Wilkinson J. R. W., Arm J. P., Spur B. W., Lee T. H. Comparison of the generation of platelet activating factor and leukotriene C4 in human eosinophils stimulated by unopsonized zymosan and by the calcium ionophore (A23187). The effects of nedocromil sodium. J. Allergy Clin. Immunol. 1990, 85, 26-35.
  60. Lee T. H., Crea A. E. G., Gant V., Spur B. W., Marron B. E., Nicolaou K. C., Reardon E., Brezinski M., Serhan C. N. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4 and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am. Rev. Resp. Dis. 1990, 141, 1453-1458.
  61. Lee T. H., Arm J. P., Horton C. E., Crea A. E. G., Mencia-Huerta J.-M., Spur B. W. The effects of dietary fish oil lipids on allergic and inflammatory diseases. Allergy Proc. 1991, 12(5), 299-303.
  62. Christie P. E., Spur B. W., Lee T. H. The effect of inhalation of the leukotriene receptor antagonist SK&F 104353 on LTC4 and LTE4-induced bronchoconstriction in asthmatic subjects. J. Allergy Clin. Immunol. 1991, 88(2), 193-198.
  63. Lee T. H., Lympany P., Crea A. E. G., Spur B. W. Inhibition of leukotriene B4-induced neutrophils migration by lipoxin A4: Structure-function relationships. Biochem. Biophys. Res. Commun. 1991, 180(3), 1416-1421.
  64. O'Hickey S. P., Hawksworth R. J., Fong C. Y., Arm J. P., Spur B. W., Lee T. H. Leukotrienes C4, D4 and E4 enhance histamine responsiveness in asthmatic airways. Am. Rev. Resp. Dis. 1991, 144(5), 1053-1057.
  65. Jacques C. A., Spur B. W., Johnson M., Lee T. H. The mechanism of LTE4-induced histamine hyperresponsiveness in guinea-pig tracheal and human bronchial smooth muscle, in vitro. Br. J. Pharmacol. 1991, 104(4), 859-866.
  66. Jacques C. A., Spur B. W., Johnson M., Lee T. H. The effect of epithelium removal on leukotriene E4-induced histamine hyperresponsiveness in guinea-pig tracheal smooth muscle. Br. J. Pharmacol. 1992, 106(3), 556-562.
  67. Christie P. E., Hawksworth R., Spur B. W., Lee T. H. The effect of indomethacin on LTE4-induced histamine hyperresponsiveness in asthmatic subjects. Am. Rev. Respir. Dis. 1992, 146(6), 1506-1510.
  68. Christie P. E., Spur B. W., Lee T. H. The effect of lipoxin A4 on airway responses in asthmatic subjects. Am. Rev. Respir. Dis. 1992, 145(6), 1281-1284.
  69. Macpherson J. L., Spur B. W., Pyne S. G., Heymans F., Cox M. F., Godfroid J. J., Krilis S. A. Production and characterization of antibodies to platelet activating factor. J. Lipid Mediat. 1992, 5(1), 49-59.
  70. Christie P. E., Schmitz-Schumann M., Spur B. W., Lee T. H. Comparison of airway responsiveness to histamine, leukotriene C4 (LTC4) and leukotriene E4 (LTE4) in aspirin sensitive asthmatic subjects with that of aspirin tolerant subjects. Am. Rev. Respir. Dis. 1993, 174(4), 856.
  71. Laitinen L. A., Laitinen A., Haahtela T., Vilkka V., Spur B. W., Lee T. H. Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 1993, 341(8851), 989-990.
  72. Soyombo O., Spur B. W., Soh C., Lee T. H. Structure - activity relationship of leukotriene B4 and its structural analogues in chemotactic -, lysosomal enzyme release - and receptor binding assays. Eur. J. Biochem. 1993, 218 (1), 59-66.
  73. Christie P. E., Schmitz-Schumann M., Spur B. W., Lee T. H. Airway responsiveness to leukotriene C4 (LTC4), leukotriene E4 (LTE4) and histamine in aspirin-sensitive asthmatic subjects. Eur. Respir. J. 1993, 1468-1473.
  74. Soyombo O., Spur B. W., Lee T. H. The effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylanaline. Allergy 1994, 49(4), 230-234.
  75. Yin K., Lai P. S., Rodriguez A., Spur B.W., Wong P.Y-K. Anti-thrombotic effects of peroxynitrite: Inhibition and reversal of aggregation in human platelets. Prostaglandins 1995, 50, 169-178.
  76. Lin K. -T., Xue J. -Y., Nomen M., Spur B. W., Wong P. Y. -K. Peroxynitrite induced apoptosis in HL-60 cells. J. Biol. Chem. 1995, 270(28), 16487-16490.
  77. Chung-a-on K. O., Soyombo O., Spur B. W., Lee T. H. Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-triphosphate generation in human neutrophils by lipoxin A4. Br. J. Pharmacol. 1996, 117(6), 1334-1340.
  78. Rodríguez A., Nomen M., Spur B. W., Godfroid J. -J. Effective stereoselective total synthesis of 16,16-dimethyl prostaglandin E2. Arch. Pharm. Pharm. Med. Chem. 1998, 331, 279-282.
  79. Rodríguez A., Nomen M., Spur B. W., Godfroid J. -J. A Selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids. Tetrahedron Lett. 1998, 39, 8563-8566.
  80. Sheu M. T., Lin L. H., Spur B. W., Wong P. Y. K., Chiang H. S. Investigation of the percutaneous penetration of prostaglandin E1 and its ethyl ester. J. Control. Release 1998, 55(2-3), 153-160.
  81. Ho H. O., Chen L. C., Spur B. W., Wong P. Y. K., Sheu M. T. The percutaneous delivery of prostaglandin E1 carried by microemulsion system. Proc. Int. Symp. Control. Release Bioact. Mater. 1998, 579-580.

Chapters in Books

  1. Koenig W., Bremm K. D., Theobald K., Pfeiffer P., Szperalski B., Bohn A., Borgeat P., Spur B., Crea A., Falsone G. Leukotrienes and lipid factors: mediators and modulators of the inflammatory reactions. Recent Adv. Immunol., Plenum Press New York 1984, 219-24.
  2. Spur B., Crea A., Peters W. Syntheses and biological effects of leukotrienes and analogs. In: Drugs affecting leukotrienes and other eicosanoid pathways (Eds. B. Samuelsson, F. Berti, G. C. Folco and G. Velo), Plenum Press, New York 1985, 39-51.
  3. Wong P. Y., Spur B., Henry P., Chao P. H., Lam B. K. Biosynthesis and metabolism of leukotrienes in response to glomeruli and neutrophil interaction of genetically hypersensitive rats. Adv. Prostaglandin Thromboxane Leukotriene Res. 1987, 17B, 736-740.
  4. Lee T. H., Arm J. P., Spur B. W. Leukotrienes and bronchial hyperreactivity. In: Allergy and Inflammation, Ed. AB Kay. Blackwell Scientific Publ. 1987, 245-259.
  5. Lee T.H., O’Hickey S. P., Jacques C., Hawksworth R. J., Arm J. P., Christie P., Spur B. W., Crea A. E. G. Sulfidopeptide leukotrienes in asthma. Adv. Prostaglandin Thromboxane Leukotriene Res. 1990, 21A, 415-419.
  6. Wong P. Y. -K., Yue G., Yin K., Liu P., Rodriguez A., Nomen M., Spur B. W., Geng J. G., Spokas E. G., Sun F. F. Anti-p-selectin antibody exacerbates inflammatory responses in acetic acid-induced colitis. Recent Advances in Prostaglandin, Thromboxane and Leukotriene Research, Eds. Sinzinger et al., Plenum Press, New York, 1997, 323-326.

Abstracts

  1. Brom J., Bremm K. D., Spur B., Crea A., Koenig W. Subcellular characterization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes. Federation Proceedings 1983, 42(3), 2441.
  2. Koenig W., Raulf M., Stuning M., Schonfeld W., Bremm K. D., Koller H., Spur B., Crea A. Characterization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes. Federation Proceedings 1984, 43(6), 1998.
  3. Sun F. F., Chau L. Y., Spur B., Corey E. J., Lewis R. A., Austen K. F. Identification of a high affinity LTC4 binding unit in rat liver cytosol as glutathione S-transferase. Federations Proceedings 1986, 46(4), 2735.
  4. Wong P.Y.-K, Spur B., Hirai A., Yoshida S., Tamura Y., Lam B. K. Biotransformation of arachidonic acid (AA) and eicosapentaenoic acid (EPA) into lipoxins and lipoxenes by porcine leukocytes. Federations Proceedings 1986, 46(4), 4494.
  5. Lam B. K., Spur B., Hirai A., Yoshida S., Tamura Y., Wong P. Y. -K. Transformation of eicosapentaenoic acid (EPA) into lipoxenes by porcine leukocytes. 6th International Conference on prostaglandins and related compounds (Florence), 1986, 188.
  6. Mahauthaman R., Youlten L. J. F., Spur B., Lee T. H. Prostaglandin, thromboxane, and leukotriene C4 generation by the human eosinophil stimulated by the calcium ionophore and unopsonised zymosan. 6th International Conference on prostaglandins and related compounds (Florence), 1986, 196.
  7. Civelli M., Sala A., Oliva D., Crea A., Spur B., Folco G. C., Nicosia S. Correlation between binding to the 3H-LTC4 sites and contraction in Guinea Pig longitudinal muscle. 6th International Conference on prostaglandins and related compounds (Florence), 1986, 352.
  8. Sun F. F., Chau L. Y., Spur B. W., Lewis R. A., Austen K. F. Characterization of LTC4 binding sites in rat liver mitochondria and microsomes. 6th International Conference on prostaglandins and related compounds (Florence), 1986, 354.
  9. Williams J., Topley N., Spur B. W., Petersen M., Steadman B. Activation of human neutrophils (PMN) by particulate zymosan and particulate yeast glucan: a comparison of leukotriene B4 (LTB4) generation and respiratory burst activity. 6th International Conference on prostaglandins and related compounds (Florence), 1986, 3366.
  10. Wong P. H. -W., Spur B., Lam B. K., Wong P. Y. -K. Biosynthesis and biological activity of lipoxins of the 5-series. Federations Proceedings 1987, 46(4), 873, #3275.
  11. Krilis S. A., Macpherson J. L., Spur B., Kemp A., Rogers M., Toia R., Chesterman C. N. Association of platelet activating factor and an endogenous inhibitor of PAF in bullous mastocytosis. Taipei Conference on prostaglandin and leukotriene research. April 22-24, 1988, 64.
  12. Spur B., Lee T. H., Crea A., Peters W. Lipoxygenase and double lipoxygenase metabolites derived from fish oil. Taipei Conference on prostaglandin and leukotriene research. April 22-24, 1988, 112.
  13. Lee T. H., Arm J. P., O' Hickey S. P., Christie P., Hawksworth R., Jacques C. A. J., Crea A. E. G., Spur B. W. Leukotrienes and lipoxins in bronchial hyperresponsiveness. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 111.
  14. Arm J. P., Hawksworth R. J., O' Hickey S. P., Smith C. M., Crea A. E. G., Spur B. W., Lee T. H. Relative responsiveness of leukotriene LTC4, LTD4 and LTE4 to histamine and methacholine in the airways of asthmatic and normal subjects, evidence for a unique relative hyperresponsiveness to LTE4 in asthmatic airways. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 113.
  15. Soyombo O., Crea A. E. G., Spur B. W., Lee T. H. Lipoxin A4 inhibits chemotactic responses of human eosinophils stimulated by PAF and FMLP. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 231.
  16. Crea A. E. G., Horton C. E., Grandordy B. M., Spur B. W., Lee T. H. Characterization of the biological activities of lipoxins on neutrophils. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 301.
  17. Crea A. E. G., Gant V. G., Spur B. W., Nicolaou K. C., Serhan C. N., Lee T. H. Identification of lipoxin A4 in the bronchoalveolar lavage fluid obtained from patients with pulmonary disease. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 317.
  18. Hawksworth R. J., O' Hickey S. P., Arm J. P., Crea A. E. G., Spur B. W., Lee T. H. Effect of inhalation of sulfidopeptide leukotrienes on airways responsiveness to histamine in asthmatic and normal subjects. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 320.
  19. Jacques C. A. J., Crea A. E. G., Spur B. W., Lee T. H. LTE4-induced hyperresponsiveness in guinea pig tracheal strips. 7th International Conference on prostaglandins and related compounds. Florence (Italy), May 28-June 1, 1990, 320.
  20. Lee T. H., Soyombo O., Crea A. E. G., Spur B. W., Nomen M., Rodríguez A., Villada H. Biological activities of LTB4 and analogues. Gordon Research Conference. Cytokines and lipid mediators as regulators of cell function. Copper Mountain (Colorado-USA), 1991.
  21. Laitinen L. A., Laitinen A., Haahtela T., Vilkka V., Spur B. W., Lee T. H. Leukotriene E4 inhalation results in eosinophil accumulation in asthmatic airways. Clinical and Experimental Allergy. British Society for allergy and clinical immunology. 1993, 23, Supplement 1, 52.
  22. Christie P. E., Spur B. W., Lee T. H. The effect of indomethacin on LTE4-induced histamine hyperresponsiveness in asthmatic subjects. Clinical and Experimental Allergy. British Society for Allergy and Clinical Immunology. February 1993, 23, Supplement 1, 80.
  23. Laitinen L. A., Laitinen A., Haahtela T., Vilkka V., Spur B. W., Lee T. H. Leukotriene E4 induces eosinophilic infiltration into asthmatic airways. The Journal of Allergy and Clinical Immunology. Fiftieth anniversary of the American academy of allergy and immunology. January 1993, 91(1,2), 349.
  24. Lin K. -T., Xue J. -Y., Nomen M., Spur B. W., Wong P.Y.-K. Peroxynitrite induced apoptosis in HL-60 cells. Eicosanoids & other bioactive lipids in cancer, inflammation & radiation injury. Hong Kong 1995.
  25. Lin K.-T., Xue J.-Y., Spur B. W., Rodríguez A., Wong P. Y.-K. Role glutathione (GSH) level on peroxynitrite-induced apoptosis in HL-60 cells. FASEB 1996 Washington DC.
  26. Wong P. Y.-K., Yue G., Yin K., Liu P., Lin M., Rodríguez A., Nomen M., Spur B. W., Geng J.-G., Sun F. F. Anti-P-selectin exacerbated inflammatory responses in acetic acid-induced colitis. International Conference on Prostaglandins and Related Compounds, Vienna (September 22-27), 1996. Prostaglandins, Leukotrienes and Ess. Fatty Acids A-176, 1996.
  27. Wong P. Y.-K., Yue G., Yin K., Liu P., Lin M., Rodríguez A., Nomen M., Spur B. W., Geng J.-G., Sun F. F. Anti-P-selectin exacerbated inflammatory responses in acetic acid-induced colitis. Inflammation Research Associates, International Conferences, Hershey, PA, (October 27-31), 1996.
  28. Spur B. W., Rodríguez A., Nomen M., Wong P. Y.-K. Simultaneous detection of eicosanoids from biological samples by HPLC-ES-MS. Annual Research Conference. UMDNJ-SOM, Stratford, NJ, February 1997.
  29. Wong P. Y.-K., Xue J. Y., Sun F. F., Nomen M., Rodríguez A., Spur B. W., Lin M. C., Liu P., Yin  K., Lin K. T. Mechanisms of peroxynitrite-induced apoptosis in HL-60 cells. Eicosanoids & other bioactive lipids in cancer, inflammation, and related diseases: 5th International Conference. Torrey Pines, La Jolla, CA, 1997.
  30. Wong P.Y.-K., Xue J. Y., Sun F. F., Nomen M., Rodriguez A., Spur B. W., Lin M. C., Liu P., Yin K., Lin K. T. On the mechanisms of peroxynitrite-induced apoptosis in HL-60 cells.  Vienna 1997.
  31. Spur B. W., Rodriguez A., Nomen M. Prostaglandins, Leukotrienes and Lipoxins: from Chemistry to Medicine. Shanghai 1997.
  32. Hock C. E., Tedesco C., Rodriguez A., Spur B. W. Dietary unsaturates and duration of feeding alter basal cardiac function and adrenergic responsiveness. Annual Research Conference. UMDNJ-SOM, Stratford, NJ. March 1999.
  33. Hock C. E., Tedesco C., Rodriguez A., Spur B. W. Dietary unsaturates and duration of feeding alter basal cardiac function and adrenergic responsiveness. Federations Proceedings 1999.
  34. Carsia R. V., Rodriguez A., Spur B. W., Hock C. E. Dietary lipids alter adrenocortical function at the cellular level. Annual meeting of the endocrine society 1999.
  35. Hock C. E., Walker J. M., Rhee S., Yin K., Rodriguez A., Spur B. W. Dietary lipids alter nitric oxide production and ventricular fibrillation (VF) in myocardial ischemia-reperfusion (I/R) Federations Proceedings 2000, # 481.15.
  36. Tuppo E. E., Forman L. J., Spur B. W., Rodríguez A., Chan-Ting R. E., Chopra A., Cavalieri, T. A. Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer’s disease. Annual Research Conference. UMDNJ-SOM, Stratford, NJ. March 2001.
  37. Hock C. E., Liu P., Walker J. M., Xu B., Rodríguez A., Spur B. W.  Dietary lipids modulate arrhythmias and the inflammatory response following myocardial ischemia-reperfusion (I/R). FASEB 2001.
  38. Hock C. E., Liu P., Patel R., Walker J. M., Xu B. H., Rodríguez A., Spur B. W. Effects of dietary unsaturates on plasma cytokines and tissue superoxide following myocardial ischemia-reperfusion (I/R). FASEB 2002.
  39. Rodriguez A.R., Spur B. W. New method for the synthesis of isoprostanes. Annual Research Conference. UMDNJ-SOM, Stratford, NJ. March 2003.
  40. Rodriguez A.R., Spur B. W. First total synthesis of  7(S), 16(R), 17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator. Annual Research Conference. UMDNJ-SOM, Stratford, NJ. March 2005.
  41. Rodriguez A.R., Spur B. W. First total synthesis of  7(S),17(S)-Resolvin D5, a potent anti-inflammatory docosanoid. Annual Research Conference. UMDNJ-SOM, Stratford, NJ. March 2006
  42. B. W. Spur and A. R. Rodriguez. Lipoxins: Resolution of inflammation. 24th Annual COSAC Autism Conference. Atlantic City. May 2006.
  43. T. P. Stein, M. D. Schluter, M. J. Leskiw, B. W. Spur, A. Rodriguez, X. Chen and T. O. Scholl. Oxidative stress and pregnancy outcome. Free Radic. Res.  2006, 40, S152-S152 Suppl. 1.
  44. E. G. Spokas, S. Harshman, J. Foglein, A. Rodriguez, G. M. Cohen and B. W. Spur. Release of the lipid peroxidation marker 8-epi-PGF2α from gill epithelial cells. Society of toxicology meeting, Charlotte, NC. March 2007.

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