Cell Biology

Faculty and Research Interests

Peitan Liu, PhD

Instructor
Science Center, Room 210
856-566-7027
liupe@umdnj.edu

Education

University of Surrey
United Kingdom, 1992

Research Interests

Work in the laboratory concerns the role of the various mediators, such as cytokines (TNF-a, IL-1b, IL-6), adhesion molecules (P-selectin, ICAM-1), and reactive oxygen species (nitric oxide, superoxide) in inflammatory development induced by ischemia-reperfusion. Currently the main focus of his lab is the study of the influence of aging on interaction of PI3K survival pathway and p53 apoptotic pathway in rat model of myocardial ischemia-reperfusion. 

Recent Publications

1. Peitan Liu, Baohuan Xu, Thomas A. Cavalieri, and Carl E. Hock. Inhibition of p53 by pifithrin-a reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock 30:545-551, 2008.
2. Peitan Liu, Baohuan Xu, Thomas A. Cavalieri, and Carl E. Hock. Inhibition of p53 by pifithrin-alpha improves cardiac function in aged rats following myocardial ischemia reperfusion. Shock 26:608-614, 2006.
3. Peitan Liu, Baohuan Xu, Thomas A. Cavalieri, and Carl E. Hock. Attenuation of antioxidative capacity enhances reperfusion injury in aged rat myocardium following myocardial ischemia-reperfusion. American Journal of Physiology Heart Circ. Physiol.287, H2719-H2727, 2004.
4. Peitan Liu, Baohuan Xu, Thomas A. Cavalieri, and Carl E. Hock. Age-related difference in inflammation and myocyte apptosis in the rat model of myocardial ischemia-reperfusion.  Cardiovascular Research,  56:443-453, 2002.
5. Peitan Liu, Baohuan Xu and Lloyd Forman, Rocco Carsia, and Carl E. Hock. L-NAME exacerbates microcirculation and cardiomyocyte apoptosis during myocardial ischemia-reperfusion. Shock, 17:185-192, 2002.
6. Peitan Liu, Baohuan Xu, and Carl E. Hock. Inhibition of nitric oxide exacerbates remote lung injury induced by hepatic ischemia-reperfusion. Shock 16 (3):212-218, 2001.
7. Liu, Peitan, Baohuan Xu, John Quilley and Patrick Y-K Wong. Peroxynitrite attenuates hepatic reperfusion injury. Am J Physiol 279:C1970-C1977, 2000.
8. Peitan Liu, Baohuan Xu, Eric Spokas, Pi-Shiang Lai and Patrick Y-K Wong. Role of Endogenous Nitric Oxide in TNF-alpha and IL-1ß Generation at mRNA and  Protein Levels  in Hepatic Ischemia-Reperfusion in Rats.  Shock 13:217-223, 2000.
9. Liu, Peitan, Baohuan Xu, Carl E. Hock, Robert Nagele, Frank Sun and Patrick Y-K Wong. Nitric Oxide Modulates P-selectin and ICAM-1mRNA Expression and Hemodynamic Alterations in Hepatic I/R. Am J Physiol 275:H2191-2198, 1998.
10. Liu, Peitan, K Yin, R Nagele and Wong P Y-K. Inhibition of NO synthase attenuates peroxynitrite generation, but augments neutrophil infiltration in the hepatic ischemia-reperfusion in rats. Journal of Pharmacology and Experimental Therapeutics 284:1139-1146, 1998.
11. Wong, P. K-Y, Yue, G., Yin, K., Liu P., Lin, M., Rodriguez, A., Nomen, M., Spur, B.W., Geng, J.G., Spokas, E.G., and Sun, F.F. Anti-P-selectin antibody exacerbated inflammatory responses in acetic acid-induced colitis. In Recent Advances in Prostaglandin, Thromboxane and leukotriene research. Eddied by Sinzinger et al., Plenum Press, NY. pp323-326, 1998.
12. Lioyd J Forman, Peitan Liu, Rebort G Nagele, Kingsley Yin and Patrick Y-K Wong. Augmentation of nitric oxide, superoxide and peroxynitrite production during cerebral ischemia and reperfusion in the rat.  Neurochemical Res. 23:141-148, 1998.
13. Peitan Liu, Carl E. Hock, Robert Nagele and Patrick Y-K Wong. Formation of nitric oxide, superoxide, and peroxynitrite production in myocardial ischemia-reperfusion injury in rat. Am. J. Physiology 272 (Heart Circ. Physiol 41):H2327-2336, 1997.
14. Wong P-KY, Yue G, Yin K, Liu P, Lin M, Rodriguez A et al.. Anti-P-selectin antibody exacerbated       inflammatory responses in acetic acid-induced colitis. Advances in Experimental Medicine & Biology    433:323-326, 1997.
15. Peitan Liu, Kingsley Yin, Gang Yue and Patrick Y-K Wong. Role of nitric oxide in hepatic ischemia-reperfusion with endotoxemia. J. Inflammation 46: 144-154, 1996.
16. McGuire GM, P Liu, Jaeschke H. Neutrophil-induced lung damage after hepatic ischemia and endotoxemia. Free Radical Biology & Medicine 20:189-197, 1996.
17. Peitan Liu, Gerald M. McGuire, Michael A. Fisher, Anwar Farhood, C. Wayne Smith, and Harmut Jaeschke. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin enhanced liver injury after hepatic ischemia. Shock 3: 56-62,1995.
18. Peitan Liu, Vonderfecht S.L., McGuire, G.M., Fisher, M.A., Farhood, A., and Jaeschke, H.M.  The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J Pharmacology and Experiment Therapeutics 271: 438-445, 1994.
19. Peitan Liu, Michael A. Fisher, Anwar Farhood, C. Wayne Smith, and Hartmut Jaeschke . Beneficial effects of extracellular glutathione against endotoxin-induced liver injury during ischemia and reperfusion. Circulatory Shock 43: 64-70, 1994.
20. Peitan Liu, Steven L. Vonderfecht, Michael A. Fisher, and Hartmut Jaeschke. Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury. Circulatory Shock 43: 9-17, 1994.
21. Peitan Liu, Farhood A, Smith C.W, and Jaeschke H. Role of Kupffer cells and neutrophils in endotoxin-induced liver injury after hepatic ischemia. Toxicologist 14:370-, 1994.
22. Peitan Liu, A.M. Symons, J.A. Howarth, P.S. Boulter and D.V. Parke (1994) Studies in surgical trauma: oxidative stress in ischemia-reperfusion of rat liver. Clinical Science, 86:453-460, 1994.
23. Peitan Liu, Ioannides C, Symons A.M., and Parke D.V. The role of tissue glutathione in prevention of surgical trauma. Xenobiotica 23:899-911, 1993.
24. Peitan Liu, P.A. Kentish, A.M. Symons, and D.V. Parke. The effect of ether anaesthesia on oxidative stress in rats-Dose response. Toxicology 80: 37-49, 1993.
25. Peitan Liu, Ioannides C, Shavila J, Symons A.M, and D.V. Parke. Effects of ether anaesthesia and fasting on various cytochrome P450 of rat liver and kidney. Biochemical Pharmacology 45:871-877, 1993.
26. Peitan Liu, A.M. Symons and D.V. Parke: Chapter 35: The effects of fasting and ether anaesthesia on hepatic and renal function in surgical trauma. P385-394. In ‘Food Nutrition and Chemical Toxicity.” Eds D.V. Parke, C. Ioannides and R. Walker, Smith-Gordon, UK, 1992.
27. Peitan Liu, A.M. Symons, and D.V. Parke (1991) Autoxidative injury with loss of cytochrome P-450 following acute exposure of rats to fasting and ether anaesthesia. Xenobiotica, 21:205-216, 1991.
28. Peitan Liu and Zunrong Goa. Relationship between free radicals and diseases. Chinese J Experimental Surgery 2:92-96, 1990.
29. Peitan Liu and Zhinying Sheng. Relationship between the M/ system and pulmonary damage. Review. Foreign Medicine-Part of Trauma 2:67-71,1990.