Cell Biology
Faculty and Research Interests
Carl E. Hock, PhD
Assistant Dean for Research
Associate Professor
Science Center 218
856-566-6078
hock@umdnj.edu
Education
University of Louisville School of Medicine,
Department of Physiology and Biophysics, PhD, 1982
Research Interests
Work in this laboratory is directed toward the study of cardiovascular function under both normal and pathophysiologic conditions (i.e., circulatory shock, myocardial ischemia, etc.). Animal models of myocardial ischemia-reperfusion injury and acute endotoxemia are currently under investigation. Current work is focused on the effect of humoral mediators and inflammatory cells (i.e., angiotensin II, nitric oxide, eicosanoids, leukocytes, macrophages etc.) in the pathophysiology of ischemic states. We are also interested in the effect of modification of dietary lipid on cardiovascular function under both normal and pathophysiologic conditions. Diet-induced modification of cell membrane lipid structure can alter the cellular response to humoral mediators, receptor mediated processes, calcium binding and fatty acid mobilization. Current investigations include both nutritional and pharmacological interventions aimed at reducing both the formation and pro-ischemic actions of mediators of cardiovascular pathology.
Relevant Publications
Liu, P., B. Xu and C.E. Hock.Inhibition of nitric oxide synthesis by L-NAME exacerbates acute lung injury induced by hepatic ischemia-reperfusion. (Accepted, Shock 2000).
Yin, K., C.E. Hock, P-S. Lai, J.T. Ross and G. Yue.Role of interferon-gamma in lung inflammation following cecal ligation and puncture in rats. Shock 12:215-221, 1999.
Liu, P., B. Xu, C.E. Hock, R. Nagele, F.F. Sun, and P. Y-K Wong.NO Modulates P-selectin and ICAM-1 mRNA expression and hemodynamic alterations in hepatic I/R. Am J. Physiol. 275:H2198, 1998.
Yin, K. C.E. Hock, M. Tahamont and P. Y-K Wong. Time-dependent cardiovascular and inflammatory changes in acute endotoxemia. Shock 9:434-442, 1998.
Liu, P., C.E. Hock, R. Nagele and P.Y-K Wong. Formation of nitric oxide, superoxide and peroxynitrite in myocardialschemia-reperfusion injury in rats. Am. J. Physiol. 272:H2327-H2336,1997.
Hock, C.E., K. Yin, G. Yue and P. Y-K Wong. Effects of inhibition of nitric oxide synthase (NOS) by aminoguanidine in acute endotoxemia. Am. J. Physiol 272:H843-H850,1997.
Forman, L.J., C.E. Hock, M. Harwell and S. Estilow-Isabell. Comparison of the effects of immobilization and pressure overload induced cardiac hypertrophy on immunoreactive beta-endorphin. Life Sciences 57:2041-2047,1995.
Carsia, R.V., D. Forman, C.E. Hock, R.G. Nagele and P.J. McIlroy. Lead (Pb2+) alters growth and reduces angiotensin II receptor density of rat aortic smooth muscle cells. Proc. Exp. Biol. Med. 210:180-190,1995.
Patel, J.P., L.D. Beck, F.A. Briglia and C.E. Hock. Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. Critical Care Medicine 23:231-237,1995.
Forman, L.J., C.E. Hock, M. Harwell and S. Isabell-Estilow. The results of exposure to immobilization, hemorrhagic shock and cardiac hypertrophy on -endorphin in rat cardiac tissue. Proc. Soc. Exp. Biol. Med. 206:124-129,1994.
Hock, C.E., L.D. Beck and L.A. Papa. Peptide leukotriene receptor antagonism in myocardial ischemia and reperfusion. Cardiovascular Research 26:1206-1211,1992
