Faculty and Research Interests

Bernd W. Spur, Ph.D.

Assistant Professor
Department of Cell Biology
Science Center 102a
2 Medical Center Drive
Stratford, NJ 08084
856-566-7016 (office)
856-566-6195 (fax)
spurbw@umdnj.edu

Education:
University Dusseldorf, West Germany, 1979.

Research Interests:
Lipid mediators of inflammation, isoprostanes, leukotrienes, lipoxins, asthma, clinical studies in areas of inflammation and alzheimers.

Relevant Publications:

Tuppo, E.E., Forman, L.J., Spur, B.W., Chan-Ting, R.E., Chopra, A. and Cavalieri, T.A. Signs of Lipid Peroxidative Damage as Measured in the Urine of Patients with Alzheimers. Brian Research Bulletin. 2001, in press.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. and Lee, T.H. Total synthesis of 12(R)-HETE, 12(S)-HETE, 2H2-12(R)-HETE and LTB4 from racemic glycidol via hydrolytic kinetic resolution. Tetrahedron, 2001, 57:25-37.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. and Lee, T.H. Total synthesis of lipoxin A4 and lipoxin B4 from butadiene. Tetrahedron Lett. 41, 823-826, 2000.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. and Lee, T.H. Total synthesis of leukotrienes from butadiene. Eur. J. Org. Chem. 2991-3000, 2000.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. and Lee, T.H. Total synthesis of 12(R)-HETE, 12(S)-HETE, 2H2 -12(R)-HETE and LTB4 from racemic glycidol via hydrolytic kinetic resolution. Tetrahedron, 57, 25-37, 2001.

Danielsson, K.G., Swahn, M.L., Marions, L., Wong, P.Y-K., Rodriguez, A., Spur, B.W. and Bygdeman, M. Comparison between oral and vaginal administration of misoprostol on uterine contractility. Obstet. Gynecol. 93(2): 275-280, 1999.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. Synthesis of 2H3-labelled misoprostol and its primary plasma metabolite. J. Labelled Cpd. Radiopharm. 42: 843-850, 1999.

Ho, H.M.C., Tseng, S. L., Lin, L.H., Chen, K.T., Chiang, H.S., Spur, B.W., Wong, P.Y-K. and Sheu, M.T. The percutaneous penetration of prostaglandin E1 and its alkyl esters. J. Control. Release 58(3): 349-355, 1999.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. Selective oxidation of primary silyl ethers and its application to the synthesis of natural products. Tetrahedron Lett. 40: 5161-5164, 1999.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J-J. An efficient asymmetric synthesis of prostaglandin E1. Eur. J. Org. Chem. 2655-2662, 1999.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid,J.-J. Effective stereoselective total synthesis of 16,16-dimethyl prostaglandin E2. Arch. Pharm. Pharm. Med. Chem. 331: 279-282, 1998.

Rodríguez, A., Nomen, M., Spur, B.W., Godfroid, J.-J. A selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids. Tetrahedron Lett. 39:8563-8566, 1998.

Sheu, M.T., Lin, L.H., Spur, B.W., Wong, P.Y-K., and Chiang, H.S. Investigation of the percutaneous penetration of prostaglandin E1 and its ethyl ester. J. Control. Release, 55(2-3): 153-160, 1998.

Chung-a-on, K.O., O. Soyombo, B.W. Spur and T.H. Lee. Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-triphosphate generation in human neutrophils by lipoxin A4. British J. Pharmac. 117:1334-1340, 1996.

Yin, K., P.S. Lai, A. Rodriguez, B.W. Spur and Wong, P.Y-K. Anti-thrombotic effects of peroxynitrite: Inhibition and reversal of aggregation in human platelets. Prostaglandins 50:169-178, 1995.

Lin K-T., J-Y. Xue, M. Nomen, B.W. Spur and P.Y-K. Wong. Peroxynitrite induced apoptosis in HL-60 cells. J. Biol. Chem. 270, No.28, 16487-16490, 1995.

Soyombo, O., Spur, B.W., and Lee, T.H. The effects of Lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylanaline. Allergy, 49(4):230-234, 1994.

Christie, P.E., Schmitz-Schumann, M., Spur, B.W., Lee, T.H.Airway responsiveness to leukotriene C4 (LTC4) leukotriene E4 (LTE4) and histamine in aspirin-sensitive asthmatic subjects. Eur. Respir. J. 1468-1473, 1993.

Laitinen L.A., Laitinen A., Haahtela T., Vilkka V., Spur, B.W., Lee T.H. Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 341:8851- 8889, 1993.

Soyombo, O., Spur, B.W., Soh, C. and Lee, T.H. Structure - activity relationship of leukotriene B4 and its structural analogues in chemotactic -, lysosomal enzyme release - and receptor binding assays. Eur. J. Biochem.218(1):59-66, 1993.

Christie, P.E., Schmitz-Schumann, M., Spur, B.W. and Lee T.H. Comparison of airway responsiveness to histamine, leukotriene C4 (LTC4) and leukotriene E4 (LTE4) in aspirin-sensitive asthmatic subjects with that of aspirin tolerant subjects. Am. Rev. Respir. Dis. 174(4): 856, 1993.

Jacques, C.A., Spur, B.W., Johnson, M., and Lee, T.H. The effect of epithelium removal on leukotriene E4-induced histamine hyperresponsiveness in guinea-pig tracheal smooth muscle. Br. J. Pharmacol. 106(3): 556-62, 1992.

Christie, P.E., Hawksworth, R., Spur, B.W. and Lee, T.H. The effect of indomethacin on LTE4-induced histamine hyperresponsiveness in asthmatic subjects. Am. Rev. Respir. Dis. 146:1506-10, 1992.

Christie, P.E., Spur, B.W. and Lee, T.H. The effect of Lipoxin A4 on airway responses in asthmatic subjects. Am. Rev. Respir.Dis. 145:1281-4, 1992.

Macpherson, J.L., Spur, B.W., Pyne, S.G., Heymans, F., Cox, M.F., Godfroid, J.J. and Krilis S.A. Production and characterization of antibodies to platelet activating factor. J. Lipid Med. Feb. 5(1):49-59, 1992.