Faculty and Research Interests

Peitan Liu, PhD

Instructor
Department of Cell Biology
Science Center, Room 210
2 Medical Center Drive
Stratford, NJ 08084
856-566-7027 (office)
8546-566-6195 (fax)
liupe@umdnj.edu

Education:
University of Surrey, United Kingdom, 1992

Research Interests:
Inflammation induced by ischemia/reperfusion of individual organs (the heart or liver in rats), and the role of the various inflammatory mediators, such as nitric oxide, TNF-alpha, and adhesion molecules (P-selectin, ICAM-1) in the inflammatory injury.Present focus is on the role of nitric oxide in the modulation of activation of apoptosis pathways in the rat model of myocardial ischemia-reperfusion.

Relevant Publications:

Liu, P., Xu, B., Quilley, J. and Wong, P.Y-K (2000) Peroxynitrite attenuates hepatic ischemia-reperfusion injury.Accepted by Am J. Physiol, in press.

Liu, P., Xu, B., Spokas, E.G., Lai, P-S and Wong, P.Y-K (2000) Role of endogenous nitric oxide in TNF-alpha and IL-1ß generation of mRNA and protein levels in hepatic ischemia-reperfusion in rats. Shock 13:217-223.

Liu, P., Xu, B., Hock, C.E., Nagele, R., Sun, F.F and Wong, P.Y-K (1998) Nitric Oxide modulates P-selectin and ICAM-1mRNA expression and hemodynamic alterations in hepatic I/R. Am J. Physiol. 275:H2191-2198.

Liu, P., Yin, K., Nagele, R. and Wong, P.Y-K. (1998) Inhibition of NOS synthase attenuates peroxynitrite generation, but augments neutrophil infiltration in hepatic ischemia-reperfusion in rats. J. Pharmacol. Exp. Ther.284:1139-1146.

Wong, P.Y-K, Yue, G., Yin, K., Liu, P., Lin, M., Rodrizuez A., et al. (1997) Anti-P selectin antibody exacerbated inflammatory responses in acetic acid-induced colitis.Advances in Experimental Medicine & Biology, 433:323-326.

Forman, L.J., Liu, P., Nagele, R., Yin, K. and Wong, P.Y-K. (1997) Augmentation of nitric oxide, superoxide and peroxynitrite production during cerebral ischemia and reperfusion in the rat. Neurochemical Research, 23(2):141-149.

Liu, P., Hock, C.E., Nagele, R. and Wong, P.Y-K. (1997) Formation of nitric oxide, superoxide and peroxynitrite production in myocardial ischemia-reperfusion injury in rat. Am. J. Physiol., 272:H2327-2336.

Liu, P., Yin, K., Yue, G. and Wong, P.Y-K (1996) Role of nitric oxide in hepatic ischemia-reperfusion with endotoxemia. J. Inflammation, 46:144-154.

McGuire, G.M., Liu, P. and Jaeschke, H. (1996) Neutrophil-induced lung damage after hepatic ischemia and endotoxemia. Free Radical Biology & Medicine, 20:189-197.

Liu, P., McGuire, G.M., Fisher, M.A., Farhood, A., Smith, CW. and Jaeshke, H. (1995) Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin enhanced liver injury after heaptic ischemia. Shock, 3:56-62.

Liu, P., Vonderfect, S.L., McGuire, G.M., Fisher, M.A., Farhood, A. and Jaeshke, H. (1994) The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J. Pharmacol. Exp. Ther., 271:438-445.

Liu, P., Fisher, M.A., Farhood, A., Smith, C.W. and Jaeshke, H. (1994) Beneficial effects of extracellular glutathione against endotoxin-induced injury during ischemia and reperfusion. Circulatory Shock, 43:64-70.

Liu, P., Vonderfecht, S.L., Fisher, M.A. and Jaeschke, H. (1994) Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury. Circulatory Shock, 43:9-17.

Liu, P., Farhood, A., Smith, C.W. and Jaeshke, H. (1994) Role of Kupffer cells and neutrophils in endotoxin-induced liver injury after hepatic ischemia. Toxicologist, 14:370.

Liu, P., Symons, A.M., Howarth, J.A., Boulter, P.S. and Parke, D.V. (1994)
Studies in surgical tramua: Oxidative stress in ischemia-reperfusion of rat
liver. Clinical Science, 86:453-460.

Liu, P., Ionnides, C., Symons, A.M. and Parke, D.V. (1993) The role of tissue glutathione in prevention of surgical trauma. Xenobiotica, 23:899-911.

Liu, P., P.A. Kentish, A.M. Symons, and D.V. Parke (1993) The effect of ether anaesthesia on oxidative stress in rats-Dose response. Toxicology, 80:37049.

Liu, P., Ioannides, C., Shavila J., Symons A.M. and D.V. Parke (1993) Effects of ether anaesthesia and fasting on various suytochrome P450 or rat liver and kidney. Biochemical Pharmacology, 45:871-877.